MyBioSource.com's TICAM2 Antibody BIOTIN-Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Dot Blot, ELISA, and Western Blot. The TICAM2 Antibody BIOTIN-Conjugated was generated using TICAM2 as the antigen and it reacts with Human, Mouse, and Rat.
Description
BIOTIN-Conjugated TRIF-related adapter molecule Antibody
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response